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Tuesday, 19 May 2015

FORCEPS DELIVERY
Obstetrical forceps are designed for extraction of the fetus. True forceps were first devised in the late 16th and beginning of the 17th century
Forceps
Obstetrical forceps is a pair of instruments specially designed to assist extraction of the fetal head and there by accomplishing delivery of the fetus.
History
The obstetrical forceps, allowing during birth, the extraction of a living child, was invented by the eldest son of the Chamberlen family of surgeons. The Chamberlens were French Huguenots working in Paris before they immigrated to England in 1569 to flee from religious violence perpetrated in France. William Chamberlen, the patriarch of the family, was most likely a surgeon; he had two sons, whom he both named Pierre, that became maverick surgeons that specialized in midwifery. William and the eldest son practiced in Southampton and then settled in London. The inventor was probably the eldest Pierre (then Peter in England), who became obstetrician-surgeon of Queen Henriette, wife of King Charles I of England and daughter of Henry IV, King of France. The forceps were used most notably in hard and difficult childbirths, ones which would most probably result in the death of the baby, because in other situations hooks or other instruments that would endanger the life of the infant were used. In the interest of secrecy, the forceps were carried into the birthing room in a lined box and would only be used once everyone was out of the room and the mother blindfolded. He was succeeded by his nephew, Dr. Peter Chamberlen (also known as Peter the Third), as royal obstetrician. The success of this dynasty of obstetricians with the Royal family and high nobles was related in part to the use of a "secret" instrument allowing release of live child in difficult cases.
The instrument was kept secret for a 150 years by the Chamberlen family, although there is evidence for its presence of as far back as 1634. Hughes Chamberlen, Grand nephew of Peter the eldest, tried to sell the instrument in Paris in 1670, but the demonstration he did in front of François Mauriceau, responsible for Paris Hotel-Dieu maternity, was a resounding failure which resulted in the death of child and mother. The secret may have been sold by Hughes Chamberlen to Dutch obstetricians at the start of the 18th century in Amsterdam, but there are doubts about the authenticity of what was actually provided to buyers.
Models derived from the Chamberlen instrument finally appeared gradually in England and Scotland in 1735. About 100 years after the invention of the forceps by Peter Chamberlen Sr. a surgeon by the name of Jean Palfyn presented his obstetric forceps to the Paris Academy of Sciences in 1723. They contained parallel blades and were called the Hands of Palfyn, which were possibly the instruments described by used in Paris by Gregoire father and son, Dussée and Jacques Mesnard.
In 1813, Peter Chamberlen’s midwifery tools were discovered at Woodham Mortimer Hall. In the attic of the house, the instruments were found along with gloves, old coins and trinkets. The tools discovered also contained a pair of forceps that were presumably invented by the father of Peter Chamberlen, assumed so because of the barbaric nature of the design.
The Chamberlen family's forceps were based on the idea of separating the two branches of sugar clamp, which were put in place one after another in the birth canal. This was not possible with conventional tweezers previously tested. However, they could only succeed in maternal pelvis of normal dimensions and on fetal heads already well engaged (i.e. well lowered into maternal pelvis). Abnormalities of pelvis were much more common in the past than today, which complicated the use of Chamberlen forceps. The absence of pelvic curvature of the branches (vertical curvature to accommodate the anatomical curvature of maternal sacrum) prohibited blades from reaching upper-part of the pelvis and exercising traction in the natural axis of pelvic excavation.
In 1747 French obstetrician Andre Levret, published "Observations sur les causes et accidents de plusieurs accouchements laborieux" (Observations on the Causes and Accidents of Several Hard Deliveries), in which he modified the instrument to follow the curvature of the maternal pelvis, allowing a grip on a fetal head still high in the pelvic excavation, which could assist in more difficult cases. This improvement was published in 1751 in England by William Smellie in the book " A Treatise on the theory and practice of midwifery." After this fundamental improvement, the forceps would become a common obstetrical instrument for more than two centuries.
The last improvement of the instrument was added in 1877 by a French obstetrician, Stephan Tarnier in "descriptions of two new forceps." This instrument featured a traction systemmisaligned with the instrument itself, sometimes called the "third curvature of the forceps". This particularly ingenious traction system, allowed the forceps to exercise traction on the head of the child following the axis of the maternal pelvic excavation, which had never been possible before. Tarnier's idea was to "split" mechanically the grabbing of the fetal head (between the forceps blades) on which the operator does not intervene after their correct positioning, from a mechanical accessory set on the forceps itself, the "tractor" on which the operator exercises traction needed to pull down the fetal head in the correct axis of the pelvic excavation. Tarnier forceps (and its multiple derivatives under other names) remained the most widely used system in the world until the development of the cesarean section.
Forceps had a profound influence on obstetrics as it allowed for the speedy delivery of the baby in cases of difficult or obstructed labor. Over the course of the 19th Century, many practitioners attempted to redesign the forceps, so much so that the Royal College of Obstetrics and Gynecologist collection has several hundred examples. In the last decades, however, with the ability to perform a cesarean section relatively safely, and the introduction of the ventouse or vacuum extractor, the use of forceps and training in the technique of its use has sharply declined.
Types of forceps
Eversince either peter 1 and peter 2  of the Chamberien family invented the forceps around A.D1600 , many designed were invented or modified. But only three varieties are commonly used in present day obstetric practice. These are
  1. Long curvedforceps with or without axis traction device
  2. Short curved forceps
  3. Kielland’s  forceps
Design of forceps
Forceps vary considerably in size and shape, but basically consist of two crossing branches. Each branch has four components, 
The blade
The shank
Lock
Handle .
Each blade has two curves , the cephalic and pelvic. The cephalic curve conforms to the shape of the fetal head, and the pelvic curve with that of the birth canal.
The cephalic curve should be larger enough to grasp the fetal head firmly with out compression . the pelvic curve corresponds more or less to the axis of the birth canal but varies considerably among different instruments. The blades are connected to the handle by the shanks, which gives the requisites length to the instrument.
The kind of articulation or forceps lock varies among different instruments. The common method of articulation consist of a socket located on the shank at the junction with the handle , in to which fits a socket similarly located on the opposite shank. This forms of articulation is commonly referred to as the English lock. A sliding lock is used in some forceps , such as Kielland forceps and allow the shank to move forward and backward independently. In some cases, the operator chooses to use an axis traction device help to maintain the appropriate vector for a necessary delivery.
Indication for forceps delivery
  1. Delay in second stage of labour  due to minor degree of cephalopelvic disproportion , persistent occipito posterior position , deep transverse arrest or secondary uterine inertia.
  2. Foetal distress in the secondary stage of labour when the fetal head is engaged.
  3. Prolapsed of the umbilical cord in the second stage of labour when the head is engaged.
  4. In the delivery of the after coming head in the breech presentation
  5. Maternal distress in the second stage of labour.
  6. Prophylaxis in maternal conditions such as
a.       Cardiac disease
b.      Hypertension
c.       Preeclampsia and eclampsia
d.       Diabetes
e.       Chronic nephritis
f.       Pulmonary tuberculosis
g.      Prophylaxis in premature infants .



Choice of forceps operations /delivery
Mid forceps (10%)
It is used when head (station )is at or near the level of ischial spine. Internal rotation of the head is often incomplete. Manual rotation may be is needed before traction.
Low forceps (90%)
The head is near the pelvic floor or even visible at the introitus. It is commonly used now a days with advantages.
Outlet forceps
It is a variety of low forceps where the head is on the perineum. Thus , all outlet forceps are low forceps but not all the forceps are outlet forceps operations.
Types of application of blades
Cephalic application
The blades are applied along the sides of the head grasping the biparital diameter in between the widest part of the blades. The long axis of the blade corresponds more or less to the occipito – mental plane of the fetal head. It is the ideal method of application as it has got a negligible compression effect on the cranium
Pelvic application
When the blades of the forceps are applied on the lateral pelvic walls ignoring the position of the head , it is called pelvic application. If the head remains unrotated , this types of application puts serious compression effect on the cranium and thus must be avoided.
Functions of forceps
¨      Traction is the most important function of the forceps. In primigravidae , the pull required is estimated to about 18kg and that in multiparae about 13kg.
¨      Its compression effects on the cranium should be minimal when correctly applied over the biparital plaine and should not be more than required to grasp the fetal head.
¨      Rotation of the head can be achieved by  Kielland forceps. However in the low forceps operation with the sagital sutures placed obliquely , with the occiput placed say at 2 or 10 ‘o’ clock position . cephalic application of the blades of ordinary forceps and traction causes rotation of the sagital suture. So as to bring it in an antero- posterior diameter of he outlet.
¨      To provide a protective cage for the head from the pressure  of the birth canal as in premature baby or to control the delivery of the after coming head to lesson the dangers of sudden decompression.
¨      One forceps blade may be used as a vectis to assist delivery of the head in caesarian section.
Criteria to be fulfilled prior to forceps operation
  1. Fetal and utero placental criteria
The fetal head must be engaged
The cervix must be fully dilated
The membranes must be ruptured
The position and station of the fetal head must be known with certainty .
  1. Maternal criteria 
No major cephalo-pelvic disproportion by clinical pelvimetry
Bladder must be emptied
Adequate analgesia .
  1. Others
Experienced operators
Verbal or written consent
                                           
Mnemonic for F-O-R-C-E-P-S
F :- Favorable head position and station
O :- Open os ( fully dilated )
R :- Ruptured membranes
C :- contraction present and consent
E :- Engaged head empty bladder
P :- pelvimetry no major CPD
S :- Stirrup,  lithotomy position
Classification of forceps delivery according to station and rotation
  1. High forceps
Head is not engaged . this types is not included in classification
  1. Mid forceps
Head is engaged in the pelvis but presenting part is above +2 station .
  1. Low forceps
Leading point of the fetal skull is + 2 or more but has not get reached th pelvic floor (1) rotation is <45 ̊ (2) rotation is >45 ̊
  1. Outlet forceps
¨      Scalp is visible at the introitus without separating the labia
¨      Fetal skull has reached the level of the pelvic floor
¨      Sagital sutures is in direct anterior posterior diameter
¨      Fetal head is at or on the perineum
¨      Rotation is <45 ̊
LOW FORCEPS DELIVERY
Low forceps delivery is the delivery of the fetal head which has descented below the level of the ischial spine . an episiotomy is done before the delivery is carried out

Preparation of the patient for forceps delivery
Indication
Maternal and foetal distress in the second stage of labour.
Types of forceps
Wrigley’s forceps is used for low forceps delivery .


Anesthesia
Pudentral block is supplemented by perineal and labial infilteration with 1% lignocain hydrochloride is quite effective in producing local anesthesia .
Catheterization
Internal examination to assess
  1. state of the cervix
  2.  membranous status
  3. Presentation and position of the head
  4. Assessment of the pelvic outlet
Episiotomy :- it may be done during traction when the perineum becomes bulged and thinned out by the advancing head.
Steps of forceps delivery
The operation consist of the following steps
®    Identification of the blades and their application
®    Locking of the blades
Step 1 identification and application of the blade
Step 2 locking of the blade
Step 3 and 4 traction and removal of the blades 
Step 1  identification and application of the blades
The identification of the blades is to be made after articulation as mentioned earlier. The left or lower blade is to be introduced first. The four fingers of the semi supinated right hand are inserted along the left lateral vaginal wall , the palmar surface of the fingers rest against the side of the head. The fingers are to guide during application and to protect the vaginal wall. The handle of the left blade during application and to protect the vaginal wall. The handle of the left blade is taken lightly by three fingers of the left hand . index , middle and thumb in a pen holding manner and is held vertically almost parallel to the right inguinal ligament
The fenestrated portion of the blade is placed on the right palm with the tip pointing upwards . the right thumb is placed at the junction of the blade and the shank .
The blade is introduced between the guiding inernal fingers and the fetal head manipulated by the thumb . as a blade is pushed up and up , the handle is carried downwards and backwards , traversing wide arc of a circle towards the left until the shank is to lie straight on the perineum. Utmost gentleness is required while introducing the blade . no assistant is usually required to hold the handle in low forceps operation . when correctly applied the blade should be in contact with the perineum and the superior surface of the handle should be directed upwards.

Introduction of the right blade
The two fingers of the left hand are now introduced in to the right lateral wall of the vagina along side the babies head. The right blade is introduced in the same manner as with left one but holding it with the right hand.
Step 2  locking of the blades
When correctly applied , the blade should be articulated with ease. Minor difficulty in locking can be corrected by depressing the handle on the perineum. In case of major difficulty the blades are to be removed , the cause are to be sought for (vide infra ) and  the blades are to be reinserted. The handle should never be forced to lock them
Step 3 and 4 traction and removal of blade
Before traction is applied , correct application of the blade to be ensured. Correct application is evidenced by
  1. easy locking
  2. the blades are equidistant from the lambdoid suture
  3. firm gripping of the head on the bipolar diameter – as judged by a few tentative pulls.

Principles
Steady but intermittent traction should be given if possible during contraction. However in outlet forceps the pull may be continuous. Strong traction is not needed as the only resistance to overcome is the perineum and the coccyx .
Gripping of the articulated forceps during traction
The traction is given by gripping the handle, placing the middle finger in between the shanks with the ring and index fingers on either side on the finger guard. During the final stage of traction , the four fingers are placed in between the shanks and the thumb which is placed on the under surface of the handles exerts the necessary force.
Direction of the pull
The direction of the pull corresponds to the axis of the birth canal. In low forceps operation depending upon the station of the head , the direction of the pull is downwards and backwards until the head comes to the perineum. The pull is then directed horizontally straight towards the operator till the head is almost crowned. The direction of pull is gradually changed to upwards and forwards , towards the mothers abdomen to deliver the head by extension. The blades are removed one after the other , the right one first . 
Following the birth of the head , usual procedures are to be taken as in normal delivery. Routine intravenous methergin 0.2 mg is to be administered with the delivery of the anterior shoulder.  Episiotomy is repaired in the usual method . laceration on the vaginal walls or perineum are to be excluded .
OUTLET FORCEPS OPERATIONS
Wrigley’s forceps are used exclusively in outlet forceps operations . perineal and vulval infiltration with 1% lignocain is enough for local anesthesia . the blades are introduced as in the low forceps operations with long curved forceps except the two fingers are to be introduced into the vagina for the application of the left blade. Traction is given holding the articulated forceps with the fingers placed in between the shank and the thumb on the under surface of the handle. The direction of the pull is straight horizontal and then upward and forwards.
      MID FORCEPS OPERATIONS
The commonest indication of the midforceps operation is following manual rotation of the head in malrotated occipito –posterior position. The commonly used forceps is long curved one with or without axis traction device. Kiellands is useful in the  hands of an experts.
Procedures
General anesthesia is preferable
  1. Introduction of the blades :- the introduction of the blades is to be done after prior correction of the malrotation .
a.       without axis traction device – the blades are introduced as in the low forceps operations. An assistant is required to hold the left handle after its introduction
b.      with axis traction device – while applying the left blade, the traction rod already attached to the blade is held backwards. During introduction of the right blade the traction –rod must be held forwards otherwise it will prevent locking of the blades.
  1. Traction
a.       with out axis traction device – The direction of pull is first downwards and backwards then and finally upwards and forwards.
b.      With axis traction device – the traction handle is to be attached to the traction rods. During traction, the traction rod  should remain parallel with the shanks. When the base of the occiput comes under the symphysis pubis , the traction rods are to be removed.

Difficulties in forceps delivery
The difficulties are encountered mainly due to faulty assessment of the case before the operative delivery is undertaken. However there is hardly any difficulty in low forceps operation.
During application of the blades – The causes are
®    Incompletely dilated cervix
®    Unrotated or non-engaged head
Difficulties in locking – The causes are
®    Application in unrotated head
®    Improper insertion of the blade
®    Failure to depress the handle against the perineum
®    Entanglement of the cord or fetal parts inside the blades.
Difficulty  in traction –The causes of failure to deliver with traction are
1.      Undiagnosed occipito – posterior position
2.      Faulty cephalic application
3.      Wrong direction of traction
4.      Mild pelvic contraction
5.      Constriction ring
Slipping of the blades -  The causes are
  • The blades are not introduces far enough
  • Faulty application in occipito posterior position. The blades should be equidistant from the sinciput and occiput. 
Complication of forceps delivery
Maternal
Immediate
¨      Injury –
®    vaginal laceration or sulcus tear,
®    cervical tear ,
®    extention of episiotomy to involve the vaginal vault ,
®    complete perineal tear.
¨      Nerve injury :- femoral (L2, 3, 4 )
®    Lumbosacral trunk (L4, 5) with mid forceps delivery
¨      Postpartum hemorrhage may be
  1. Traumatic
  2. Atonic requiring blood transfusion  
  3. Both may cause shock
Anesthetic complications
Purperial sepsis and maternal morbidity
Remote
®    Painful perineal scars
®    Dyspareunia
®    Lowback ache
®    Genital prolapse
®    Stress urinary incontinence
®    Sphincter  dysfunction

Fetal
Ø  Immediate
Ø  Asphyxia
Ø  Facial brusing
Ø  Intracranial hemorrhage
Ø  Cephal hematoma
Ø  Facial palsy
Ø  Skull fracture
Ø  Cervical spine injury  
Remote
Cerebral or spastic palsy due to residua cerebral injury
Nursing diagnosis
  1. Alteration in comfort due to pain related to delivery process
®    Assess the types of pain ,types , duration and intensity
®    Provide comfortable  left lateral position to the mother
®    Provide psychological reassurance  to the mother
  1. Potential for complication related to forceps application
®    Assess for any types of laceration
®    Maintain aseptic technique
®    Handle the case carefully
®    Case should handle by experts
®    Clean the perineal area with betadine
  1. Potential for infection  related to forceps application
®    Assess for any scar
®    Maintain strict aseptic technique
®    Clean the surrounding
®    Avoid many visitors
  1. Fear and anxiety of parents related to delivery process
®    Provide proper explanation about babies condition
®    Give information about progress of delivery frequently
®    Provide psychological reassurance to the mother 

®    Clarify the mother doubts 

Monday, 18 May 2015

DRUGS USED IN MIDWIFERY




DRUGS USED IN OBSTETRICS


Hyperemisis  gravidarum
Zofran: This is an antiemetic that is effective against vomiting and nausea. Although it's a newer drug, preliminary studies indicate that it causes no harm to either Mother or Baby.
Reglan: Used more often in treating GERD (gastroesophageal reflux disease), this is also effective in many cases and is considered safe for use during pregnancy.
Premature Labor: The aim of medication in preterm labor is to prevent delivery for as long as possible, with a focus on holding off delivery for at least 24 hours to allow time for lung-strengthening steroids to take effect on the baby. Depending on the pregnancy, the patient and the progression of the preterm labor, the following medications may be used:
Terbutaline: Used most commonly to treat asthma, terbutaline is thought to relax the muscles of the uterus.
Procardia: A calcium channel blocker, this treats pregnancy-induced hypertension and inhibits preterm labor.
Indomethacin: Given as a suppository in the short term. Delays premature labor by reducing uterine contractions through inhibition of prostaglandins.
Magnesium sulfate: Used to treat pre-eclampsia, eclampsia and preterm labor.
Glucocorticoids: Administered, often in two doses, to stimulate growth in the lungs of the fetus.
Induction of Labor: This is often done for a variety of medical reasons and rarely just for convenience. A patient who is being induced will be watched carefully for rare side effects that are possible with the following medications:
Cervidil and Cytotec: Both are administered as vaginal suppositories to ripen the cervix prior to delivery. This is the first step in preparing the cervix to respond to contractions. Cytotec, while very effective, has been implicated in some uterine ruptures and should not be used under certain circumstances.
Pitocin: The synthetic form of oxytocin, which is a natural hormone produced by a woman's body, Pitocin is used to start or improve contractions.




Drugs Used for Delivery

By far the most common use of all drugs in active labor are for pain relief. There are some of the medications anesthesiologists and nurse anesthetists use to help patients in labor:
Narcotics: Marketed under various names, narcotics are used early in labor to take the edge off pain. They're generally administered by injection or intravenously. The drawbacks are that they do cross the placenta and should not be given if birth is imminent or if labor is progressing quickly.
Sedatives: Given to ease anxiety, these are usually injected. They do not provide pain relief and are not commonly used unless the patient is in very early labor.
Nitrous oxide: This is used frequently in the United Kingdom, less so in the United States, mostly for reasons having to do with ventilation issues. This is an inhaled gas that can ease pain early in labor.

  1.  Prostaglandins and oxytocics

Induction and augmentation of labour
         Dinoprostone vaginal gel 1mg and 2mg
         Oxytocin injection 5units/ml, 10units/ml
         Dinoprostone vaginal pessaries 10mg

Prevention and treatment of haemorrhage
          Carboprost injection 250 microgram/ml
          Ergometrine injection 500 microgram/ml
          Oxytocin with ergometrine (Syntometrine®)

Induction of abortion – Consultant only
           Misoprostol tablets 200micrograms [unlicensed]

 Ductus arteriosus
Maintenance of patency
          Alprostadil intravenous solution 500 microgram/ml
          Dinoprostone 1mg/ml 0.75ml amp [unlicensed]

Closure of ductus arteriosus
          Indometacin injection 1mg

  1. Mifepristone
          Mifepristone tablets 200mg

  1.  Myometrial relaxants

          Salbutamol solution for intravenous infusion 5mg/5ml

     Nifedipine capsules 5mg, 10mg - Three times daily preparations
                   (only for Raynaud’s, achalasia and pre-term labour [unlicensed])

Drugs used to modify uterine contractions.
These include oxytocic drugs used to stimulate uterine contractions both in induction of labour and to control postpartum haemorrhage and beta2 -adrenoceptor agonists used to relax the uterus and prevent premature labour.
POSTPARTUM HAEMORRHAGE
  Ergometrine and oxytocin differ in their actions on the uterus. In moderate doses oxytocin produces slow generalized contractions with full relaxation in between; ergometrine produces faster contractions superimposed on a tonic contraction. High doses of both substances produce sustained tonic contractions. Oxytocin is now recommended for routine use in postpartum and  post-abortion haemorrhage since it is more stable than ergometrine. However, ergometrine may be used if oxytocin is not available or in emergency situations.
PREMATURE LABOUR
  Salbutamol is a beta2 -adrenoceptor agonist which relaxes the uterus and can be used to prevent premature labour in uncomplicated cases between 24 and 33 weeks of gestation. Its main purpose is to permit a delay in delivery of at least 48 hours. The greatest benefit is obtained by using this delay to administer corticosteroid therapy or to implement other measures known to improve perinatal health. Prolonged therapy should be avoided since the risks to the mother increase after 48 hours and the response of the myometrium is reduced.
ECLAMPSIA AND PRE-ECLAMPSIA
 Magnesium sulfate has a major role in eclampsia for the prevention of recurrent seizures. Monitoring of blood pressure, respiratory rate and urinary output is carried out, as is monitoring for clinical signs of overdosage (loss of patellar reflexes, weakness, nausea, sensation of warmth, flushing, double vision and slurred speech—calcium gluconate injection (section 27.2) is used for the management of magnesium toxicity).
  Magnesium sulfate is also used in women with pre-eclampsia who are at risk of developing eclampsia; careful monitoring of the patient (as described above) is necessary.

Ergometrine maleate

Ergometrine is a representative oxytocic drug. Various drugs can serve as alternatives
Tablets, ergometrine maleate 200 micrograms
Injection (Solution for injection), ergometrine maleate 200 micrograms/ml, 1-ml ampoule
NOTE.
Injection requires transport by ‘cold chain’ and refrigerated storage
Uses:
prevention and treatment of postpartum and post-abortion haemorrhage in emergency situations and where oxytocin not available
Contraindications:
induction of labour, first and second stages of labour; vascular disease, severe cardiac disease especially angina pectoris; severe hypertension; severe renal and hepatic impairment; sepsis; eclampsia
Precautions:
cardiac disease, hypertension, hepatic impairment (Appendix 5) and renal failure (Appendix 4), multiple pregnancy, porphyria; interactions: Appendix 1
Dosage:
Prevention and treatment of postpartum haemorrhage, when oxytocin is not available, by intramuscular injection, ADULT and adolescent 200 micrograms when the anterior shoulder is delivered or immediately after birth
Excessive uterine bleeding, by slow intravenous injection, ADULT and adolescent 250–500 micrograms when the anterior shoulder is delivered or immediately after birth
Secondary postpartum haemorrhage, by mouth , ADULT and adolescent 400 micrograms 3 times daily for 3 days
Adverse effects:
nausea, vomiting, headache, dizziness, tinnitus, abdominal pain, chest pain, palpitations, dyspnoea, bradycardia, transient hypertension, vasoconstriction; stroke, myocardial infarction and pulmonary oedema also reported

Magnesium sulfate

Injection (Solution for injection), magnesium sulfate 500 mg/ml, 2-ml ampoule, 10-ml ampoule
Uses:
 prevention of recurrent seizures in eclampsia; prevention of seizures in pre-eclampsia
Precautions:
hepatic impairment (Appendix 5); renal failure (Appendix 4); in severe hypomagnesaemia administer initially via a controlled infusion device; interactions: Appendix 1
Dosage:
Prevention of recurrent seizures in eclampsia, by intravenous injection , ADULT and adolescent initially 4 g over 5–15 minutes followed either by intravenous infusion , 1 g/hour for at least 24 hours after the last seizure or by deep intramuscular injection 5 g into each buttock then 5 g every 4 hours into alternate buttocks for at least 24 hours after the last seizure; recurrence of seizures may require additional intravenous injection of 2 g
Prevention of seizures in pre-eclampsia, by intravenous infusion , adult and adolescent initally 4 g over 5–15 minutes followed either by intravenous infusion , 1 g/hour for 24 hours or by deep intramuscular injection 5 g into each buttock then 5 g every 4 hours into alternate buttocks for 24 hours; if seizure occurs, additional dose by intravenous injection of 2 g
DILUTION AND ADMINISTRATION.
According to manufacturer’s directions
For intravenous injection concentration of magnesium sulfate should not exceed 20% (dilute 1 part of magnesium sulfate injection 50% with at least 1.5 parts of water for injection); for intramuscular injection , mix magnesium sulfate injection 50% with 1 ml lidocaine injection 2%
Adverse effects:
generally associated with hypermagnesaemia (see also notes above), nausea, vomiting, thirst, flushing of skin, hypotension, arrhythmias, coma, respiratory depression, drowsiness, confusion, loss of tendon reflexes, muscle weakness; see also Appendix 2

Oxytocin

 Injection (Solution for injection), oxytocin 10 units/ml, 1-ml ampoule
Uses:
routine prevention and treatment of postpartum and post-abortion haemorrhage; induction of labour
Contraindications:
hypertonic uterine contractions, mechanical obstruction to delivery, fetal distress; any condition where spontaneous labour or vaginal delivery inadvisable; avoid prolonged administration in oxytocin-resistant uterine inertia, in severe pre-eclamptic toxaemia or in severe cardiovascular disease
Precautions:
induction or enhancement of labour in presence of borderline cephalopelvic disproportion (avoid if significant); mild to moderate pregnancy-associated hypertension or cardiac disease; age over 35 years; history of low-uterine segment caesarean section; avoid tumultuous labour if fetal death or meconium-stained amniotic fluid (risk of amniotic fluid embolism); water intoxication and hyponatraemia (avoid large volume infusions and restrict fluid intake); caudal block anaesthesia (risk of severe hypertension due to enhanced vasopressor effect of sympathomimetics); interactions: Appendix 1
Dosage:
Induction of labour, by intravenous infusion, ADULT and adolescent , initially 0.001–0.002 units/minute increased in 0.001–0.002 units/minute increments at intervals of 30 minutes until a maximum of 3–4 contractions occur every 10 minutes; maximum recommended rate 0.02 units/minute; no more than 5 units should be administered in 24 hours
NOTE..
The dose shown above is suitable for use in hospital where equipment to control the infusion rate is available; alternative recommendations may be suitable for other settings (consult Managing Complications in Pregnancy and Childbirth : A guide for midwives and doctors 2003 . Geneva: WHO)

IMPORTANT.
Careful monitoring of fetal heart rate and uterine motility essential for dose titration (never give intravenous bolus injection during labour); discontinue immediately in uterine hyperactivity or fetal distress
Prevention of postpartum haemorrhage, by slow intravenous injection , ADULT and adolescent 5 units when the anterior shoulder is delivered or immediately after birth
Prevention of postpartum haemorrhage, by intramuscular injection , adult and adolescent 10 units when the anterior shoulder is delivered or immediately after birth
Treatment of postpartum haemorrhage, by slow intravenous injection , adult and adolescent 5–10 units or by intramuscular injection , 10 units, followed in severe cases by intravenous infusion , a total of 40 units should be infused at a rate of 0.02–0.04 units/minute; this should be started after the placenta is delivered
DILUTION AND ADMINISTRATION.
According to manufacturer’s directions. Prolonged intravenous administration at high doses with large volume of fluid (for example in inevitable or missed abortion or postpartum haemorrhage) may cause water intoxication with hyponatraemia. To avoid: use electrolyte-containing diluent (not glucose), increase oxytocin concentration to reduce fluid, restrict fluid intake by mouth; monitor fluid and electrolytes
Adverse effects:
uterine spasm, uterine hyperstimulation (usually with excessive doses—may cause fetal distress, asphyxia and death, or may lead to hypertonicity, tetanic contractions, soft-tissue damage or uterine rupture); water intoxication and hyponatraemia associated with high doses and large-volume infusions; nausea, vomiting, arrhythmias, rashes and anaphylactoid reactions also reported

Salbutamol

Salbutamol is a representative myometrial relaxant. Various drugs can serve as alternatives
Tablets , salbutamol (as sulfate) 4 mg
Injection (Solution for injection), salbutamol (as sulfate) 50 micrograms/ml, 5-ml ampoule
Uses:
 uncomplicated premature labour between 24–33 weeks gestation; asthma (section 25.1)
Contraindications:
first and second trimester of pregnancy; cardiac disease, eclampsia and pre-eclampsia, intra-uterine infection, intra-uterine fetal death, antepartum haemorrhage, placenta praevia, cord compression, ruptured membranes
Precautions:
monitor pulse and blood pressure and avoid over-hydration; suspected cardiac disease, hypertension, hyperthyroidism, hypokalaemia, diabetes mellitus; if pulmonary oedema suspected, discontinue immediately and institute diuretic therapy; interactions : Appendix 1
Dosage:
Premature labour, by intravenous infusion , ADULT initially 10 micrograms/minute, rate gradually increased according to response at 10-minute intervals until contractions diminish then increase rate (maximum of 45 micrograms/minute) until contractions have ceased, maintain rate for 1 hour then gradually reduce; or by intravenous or intramuscular injection , ADULT 100–250 micrograms repeated according to response, then by mouth , 4 mg every 6–8 hours (use for more than 48 hours not recommended)
Adverse effects:
nausea, vomiting, flushing, sweating, tremor; hypokalaemia, tachycardia, palpitations, and hypotension, increased tendency to uterine bleeding; pulmonary oedema; chest pain or tightness and arrhythmias; hypersensitivity reactions including bronchospasm, urticaria and angioedema reported


Dinoprostone (vaginal gel, vaginal tablets) is the drug of choice for induction of labour.  The two preparations are not bioequivalent, the usual dose of gel being 1 - 2mg, whereas that of the tablets is 3mg.
Dinoprostone 10mg vaginal delivery system (Propess®) is a new pessary formulation available for initiation of cervical ripening in patients at term (from 38th week of gestation). The new pessary formulation releases approximately 10mg dinoprostone over 24 hours and can remain in place for up to 24 hours where necessary.
Gemeprost (pessaries) is used to soften and dilate the cervix before induction of abortion.  In order to ensure that the patient receives maximum benefit from the drug, it is essential that the pessary is inserted as near as possible to 3 hours before the operative procedure is due to be carried out.  Gemeprost is also used in conjunction with mifepristone (see special indications).
Oxytocin (injection) is given by slow intravenous infusion for induction and augmentation of labour.  Guidelines for the use of this product are included in the Aberdeen Maternity Hospital labour ward protocol/Dr. Gray's labour ward protocol.
Syntometrine® (injection) is a combination of oxytocin (5 units) and ergometrine maleate (500 micrograms) in 1mL.  It is given by intramuscular injection for the routine management of the third stage of labour.  It is also the drug of choice in the management and prevention of post-partum haemorrhage, and for the control of bleeding due to incomplete abortion.  Its use is contra-indicated in patients with pre-eclampsia.  It is used in accordance with the guidelines included in the Aberdeen Maternity Hospital labour ward protocol.
Ergometrine maleate (injection) is used for the management of post-partum haemorrhage.
NICE guidance (induction of labour)
The National Institute for Clinical Excellence has recommended that:
·         dinoprostone is preferable to oxytocin for induction of labour in women with intact membranes regardless of parity or cervical favourability.
·         dinoprostone or oxytocin are equally effective for the induction of labour in women with ruptured membranes, regardless of parity or cervical favourability.
·         intravaginal dinoprostone preparations are preferable to intracervical preparations.
·         oxytocin should not be started for 6 hours following administration of vaginal prostaglandins.
·         when used to induce labour, the recommended dose of oxytocin by intravenous infusion is initially 0.001-0.002 units/minute increased at intervals of at least 30 minutes until a maximum of three to four contractions occur every 10 minutes (0.012 units/minute is often adequate); the maximum recommended rate is 0.032 units/minute (licensed max. 0.02 units/minute).
SPECIAL INDICATIONS
Dinoprostone (extra-amniotic solution) is indicated only for rare cases of failed medical termination of pregnancy.
Mifepristone (tablets) is used in conjunction with gemeprost pessaries or misoprostol (tablets) [unlicensed indication] for the medical termination of pregnancy (see protocol).  It is also used to soften and dilate the cervix before mechanical cervical dilation for termination of pregnancy.
Carboprost (injection) is used to treat post-partum haemorrhage in patients who do not respond to Syntometrine®.
Ritodrine (tablets, injection) is a beta2-adrenoceptor stimulant, which causes relaxation of uterine muscle.  It is used in selected cases to inhibit premature delivery.  Care and close monitoring are required, especially when given by infusion.  There is a particular danger of pulmonary oedema developing in patients with a cardiac history or when steroids are used concurrently.  Guidelines for use are included in the Aberdeen Maternity Hospital labour ward protocol/Dr. Gray's labour ward protocol.
Atosiban (injection) may be used under the supervision of a consultant obstetrician to delay imminent birth in uncomplicated pre-term labour.  See prescribing protocol.